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Lugoff was named for Count Lugoff (Loo'goff), a Russian engineer, who helped build the Seaboard Air Line Railway in 1899. Lugoff is one of many stations in Kershaw County for the Seaboard Railway. Count Lugoff brought many Russian laborers to work on the construction, but what became of them afterwards is unknown.

Lugoff is located on Highway 1 and is four miles west of Camden. It is the home of the multimillion-dollar Invista Plant, formerly DuPont, and it is also the birthplace of Brook Benton, best known for recording "Rainy Night in Georgia".

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